ArticleLanghof HJ.
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Dec 31;204(4):265-74.
The electrical response of the light adapted human eye to onset (a-wave) and offset (d1-wave of the positive off-effect) of monochromatic test stimuli between 448 and 654 nm (Ganzfeld stimulation, duration of test flash 0.3 s) was recorded by means of the electroretinogram in 10 normal observers during steady illumination of various wavelengths of 2.2 log Troland. During exposure to white light the spectral sensitivity of the a-wave and off-effect as determined by a criterion amplitude of 25 micronV were similar, the sensitivity of the off-effect being 0.4 log units lower as compared to the a-wave. Blue adaptation (467 nm) decreased the sensitivity of the a-wave and increased the sensitivity of the off-effect within the short wavelengths region of the spectrum. Red adaptation (630 nm) decreased the sensitivity of the a-wave and increased the sensitivity of the off-effect within longer wavelengths. Green adaptation (530 nm) produced only a small decrease of sensitivity of the a-wave for green test light, the sensitivity of the off-effect remained constant. The opposite changes of the a-wave and off-effect during chromatic adaptation demonstrate different participation of these components in the generation of color mechanisms in the human retina.